Some common skin diseases - Disease Pemphigus

Pemphigus noun meaning of bullous (phlyctene), is dedicated to the group of diseases characterized by: Losing the link between epidermal cells, clinical manifestations are bullous and on histological phenomenon ------------------ consumption spikes

1. BASIS OF NATURAL AND pathogenesis Pemphigus is an autoimmune disease manifestations in the skin and mucous membranes, have autoantibodies in the blood against cell surface antigens and autoantibodies keratinocyt in both skin lesions and skin healthy. The genetic mutations in patients with pemphigus impact on the cellular immune competence, these cells circulating antibodies and antibody spot. The antibodies associated with the antigen under the action of the complement system disorders causing yeast, which activates plasminogen to release substances plasmin. plasmin destroying chemicals and soluble intercellular adhesive causing skin lesions. 2. CLINICAL MANIFESTATIONS a- Body malignant (pemphigus vulgaris) Expression in the skin: An injury to or met with bullous essentially large, shallow wrinkled, application forms, the skin appears normal on the fast break to put the background skin slippery, wet and scabbed more . Originally hurt less, localized in a particular region and mucosal interstitial region and then spread throughout the body, starting with the mucosa some time after the new skin Crystal positive Nikolsky sign (hand or rubbing lightly clamp down on the edge bullous skin or normal skin, the skin slipped off or bullous form new) Body: high fever, chills patients with intermittent fatigue dizzy patients, neurological disorders, depression and rapid weight loss, body smells like dead toads, patient declined rapidly lead to death within 6 months to 1 year. Nowadays, because of scientific advances, have better prognosis but problem is intractable disease mortality rate is very high. b- The other: - Pemphigus rough: (vegtant) This rare and can be considered a period of pemphigus progressed normally. Damage is fundamentally broken bullous skin quickly leaving skid patches, then rough up the array papilloma pus, scaly weather, location and selective mucosal folds large interstitial (armpits, under the breasts, groin and buttocks). Patients may find itchy, smelly stinky, or fever and digestive disorders. After treatment or natural rough crowd and eventually collapse took leave bruises. Over the course progresses, patients with fever and loose bowel and exhaustion and died within three years. - Pemphigus skin fat: (Seborrheique) Damage is essentially vesicular, bullous skin on the fast break that left erythematous, scaly thick yellow secretion, taking mucus glands in the region: Face, chest, between the two shoulders, waist , at the very hurt butterfly, tend to atrophy of the skin, mucosa unscathed. Full good little patient affected, this can usually be less severe - Pemphigus leaf flakes (foliace) Rare disease, bullous start small farm wrinkled, position in the face, back, abdomen. lesions may appear on healthy skin patches or red skin, mucosa not hurt, bullous disappear very quickly, was replaced by patches of erythema, scaling drip, accompanied by itching and fever, signs Nikolsky positive. 3. TREATMENT Spot: potassium permanganate bath, apply the dye solution, severe cases to bed powder Body: - Use corticoits: loading dose of 1 -2 mg / 1 kg of body weight / day, combined intravenous and oral, tapering and maintained for several months or a lifetime, when to dose exacerbation frequency the back - Immunosuppressive Drugs: Methotrexzt 20 mg / week intramuscularly. Cyclophtphamid 199 mg / day - Symptomatic treatment: antibiotics, intravenous fluids, blood transfusions, preventive monitoring and treatment of gastrointestinal complications, hypertension, diabetes ...